Directions
St Louis Missouri
to Madison Indiana

Directions
to Madison Indiana
from St Louis Missouri

If you are not starting near the center of downtown St Louis Missouri, it may be best to jump on the I255 before heading over.

Whether you take I64 or I70, you'll find it to be a peaceful view along the way.

Remember: make sure your devices are fully charged with charging cords/adapters, cell phones, etc. I always suggest taking an actual paper map too!

This path from St Louis Missouri to Madison Indiana is 301 miles. The shortest path in time is estimated to be 4 hours 44 minutes.